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This was the most striking difference between Juul users and users of other e-cigarettes and conventional cigarettes, and it raises concerns about higher rates of addiction among Juul users, Halpern-Felsher said

We measured ROI to ROI connectivity at this step by measuring BOLD correlation between an ROI defined by the MDMR-identified region and a DMN ROI ( Cohort 2: Network Effects of Acute Nicotine Administration Whole-Network Connectivity Values In Cohort 1, we observed a relationship between a pathologically expanded DMN topography and greater daily nicotine use