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Collectively, these results suggest that PI3K/AKT signaling pathway activation may be involved in the pathogenesis of CS-induced pulmonary EMT and has potential therapeutic significance in COPD, lung cancer, and other smoking-related diseases

Examination of potential selection bias into the HOPE cohort produced reassuring results, with all associations demonstrating RORs containing 1 in the 95% CI, corresponding to no difference between the two populations

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