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As nicotine enhances the transcription of uPA/uPAR, it is possible that uPAR could be another clinically important player triggered by nicotine in the development of cancer [79]

G., Carru, C

Youth who attempted to quit e-cigarettes fairly resembled the total population according to age, whereas attempting to quit cigarettes was more prevalent among those aged 2529 years (51.8%), and attempting to quit smokeless nicotine was more prevalent among participants aged 1824 years (60.1%)

The WHO estimates that a single 4560-minute session can expose the user to smoke volumes far exceeding those of a single cigarette - potentially the equivalent of 100+ cigarettes