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FIGURE 1 Data source Exposures: Smoking, alcohol consumption, and coffee consumption Age of initiation smoking, cigarettes per day, smoking cessation, smoking initiation, coffee consumption, and drinks per week were selected as the six exposure variables of substance use relevant to this study ( N = 341,427), cigarettes per day (CPD, N = 337,334), smoking initiation (showing an individual had ever smoked regularly, N = 1,232,091), and smoking cessation ( N = 547,475)

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