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Second, we estimated multivariable linear regression models of cigarettes smoked per day, conditional on the frequency of vaping (categorized as every-day, some-days, ever but no longer, never), psychological distress (categorized as NPD, MPD, and SPD), the interaction of vaping and psychological distress (these variables were demeaned, or centered so that main effect coefficients could be directly interpreted 26 ), and other covariates described above

This condition causes heavy damage to the capillary wall and is quite noticeable when it is formed close to the surface of the skin