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It has been reported that excessive activation of mTOR pathway can lead to impaired mitophagy (Zhang et al., 2021)

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et al, A Randomized Trial of E-Cigarettes versus Nicotine-Replacement Therapy, New England Journal of Medicine , January 2019, Yadira Galindo, University of California-San Diego, Americans are quitting smoking in higher numbers, ScienceDaily, July 26, 2017, [15] Public Health England, E-cigarettes around 95% less harmful than tobacco estimates landmark review, news release, August 19, 2015, [16] Michelle Roberts, E-cigarettes should be offered to smokers, say doctors, BBC News, April 28, 3016, [17] The National Academies of Sciences, Engineering, and Medicine, Public Health Consequences of E-Cigarettes, Consensus Study Report Highlights, The National Academies Press, January 2018, p

Well, rehab can be a part of this process, but the picture is complicated