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In a large sample of healthy young adults, this parieto-occipital region is typically a part of the DAN, suggesting that the extension of the DMN into this region in heavy smokers with schizophrenia represents schizophrenia-specific pathologic organization ( Figure 3 To summarize, in schizophrenia, the strongest functional connectivity correlate of nicotine consumption in the brain is driven by variation in the topography of resting-state networks