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Our key observation was a significant decrease in transcript levels of molecules essentially involved in mitochondrial biogenesis in peripheral lung tissue and PBECs from COPD patients, especially in a very severe disease stage

Although petrolatum remains the most preferred vehicle irrespective of the nature of test substance, it is crucial to use water and alcohol as vehicles additionally for preparing test substances in view of frequent false-negative reactions from petrolatum

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Over months or years, this can lead to chronic kidney disease, especially in patients who are already taking ACE inhibitors or diuretics