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Accelerated Decline in Lung Function Smoking causes chronic bronchitis and speeds up lung function decline , a COPD hallmark

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Localized promoter hypermethylation has been observed in bronchial epithelial cells following combined exposure, leading to changes in cell cycle progression (e.g., reduced G1 and increased S phase) ( CDKN2A and RASSF1A in response to radon and tobacco smoke, respectively, two key regulators of cell cycle control and apoptosis (103108)