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dose related) Abnormal dreams Headache Insomnia 1-10% Appetite changes Chest pain Constipation Dry mouth Dyspepsia Dyspnea Flatulence Gastroesophageal reflux disease (GERD) Fatigue or lethargy Pruritus Rash Somnolence Rhinorrhea Vomiting Upper respiratory tract disorder Frequency Not Defined (selected) Abnormal liver function tests Anemia Anxiety Arrhythmia Arthralgia Depression Diarrhea Dizziness Epistaxis Hypertension Myocardial infarction (MI) Polyuria Respiratory disorder Postmarketing Reports Depression, mania, psychosis, hallucinations, paranoia, delusions, homicidal ideation, aggression, hostility, anxiety, and panic, as well as suicidal ideation, suicide attempt, and completed suicide, somnambulism Serious skin reactions, including Stevens-Johnson syndrome Cerebrovascular accident Seizures MI Cardiovascular: During nontreatment follow-up to 52 weeks, adjudicated events comparing patients with stable cardiovascular disease to premarket studies included need for coronary revascularization (2.0% vs 0.6%), hospitalization for angina pectoris (1.7% vs 1.1%), and new diagnosis of peripheral vascular disease (PVD) or admission for PVD procedure (1.4% vs 0.6%) Irritability Agitation Somnambulism Warnings Contraindications Documented hypersensitivity or skin reactions to drug or components of formulation Nonsmokers Cautions May cause nausea
