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Many customers often ask what happens to a nicotine pouch that has surpassed its use-by date, including whether they turn bad and if they are still safe to use

Cotinine can be detected in drug tests for a very long time due to its long half-life

These uncertainties can be attributed, in part, to the limitations of observational studies, alongside small cohorts for this relatively rare cancer, heterogeneity in study design between cohorts, and lack of distinction between HPV-positive and negative HNSCC within the studies