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In that study, the application and reapplication of the instrument were carried out in different manners, a methodological limitation that might have interfered with the coefficient of reliability, affecting the result of the investigation.(24) In the third study, two groups (individuals with and without schizophrenia) were investigated in a study on the reliability of the FTND.(34) The authors found that the correlation coefficient was lower (0.65) in the group with schizophrenia, although, again, the interval between FTND applications was not reported

Epidemiological studies have shown a four- to sixfold increased risk of lung cancer in patients with COPD, with the onset of lung cancer associated with the severity of COPD [53, 54]

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