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According to the American Heart Association, nicotine use can potentially cause an increase in: Blood pressure Heart rate Flow of blood to the heart Narrowing of the arteries, or vessels that carry blood On top of that, nicotine use can cause the hardening of the arterial walls, which in turn, may lead to a heart attack

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However, these studies only explored the association of cancer incidence with tobacco consumption and did not examine the role of dysbiosis in oral microbiome due to tobacco consumption in the progression of the disease

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