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Superantigens of specific bacteria (Streptococcus, Staphylococcus) and viruses (EpsteinBarr virus (EBV)) bypass the processing of antigen-presenting cells through directly binding to MHC II molecule T-cell receptors outside the conventional antigen-specific variable chains, initiating massive T-cell activation (up to 20% of total)

Crit Rev Oncol Hematol (2013) 88(3):494503.10.1016/j.critrevonc.2013.06.011 26 RamrezNzelMZLewisACMarcRMBorrullFHamiltonJF

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You might remember that the Prefrontal Cortex is the place in the brain that the reward pathway terminates (see Figure 1.9)