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A Cochrane Review on HTP found there was moderatecertainty evidence that heated tobacco users have lower exposure to toxicants/carcinogens than cigarette smokers.[ii] This systematic review included only randomised controlled trials, but as these were mostly paid for by tobacco companies, its authors did raise the need for independently funded research

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The combined effect of these factors often results in more pronounced digestive responses than with nicotine-only products

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