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An e-cigarette or Electronic Nicotine Delivery System (ENDS) is a battery-operated smoking device that creates an aerosol by heating a mix of liquid nicotine, propylene glycol, water, glycerine and flavour, which, when inhaled, gives the feel of smoking a real cigarette

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Long-term hypertension, diastolic dysfunction, increased cardiac after-load, myocardial fibrosis, alterations in coronary flow reserve, and ultimately left ventricular hypertrophy can result from endothelial failure besides vasoconstrictors up-regulation passageways (183)