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doi: 10.1001/jama.2023.17134 4

These include: Diacetyl: Linked to bronchiolitis obliterans (popcorn lung) Formaldehyde: A toxic chemical linked to airway irritation Acrolein: A chemical used in pesticides that can damage lung tissue and airways Acetaldehyde: Irritates airways and can cause inflammation Nitrosamines: Found in certain nicotine products and are associated with cancer risk Although levels vary across devices and brands, repeated inhalation and exposure to these substances can accelerate lung damage and contribute to COPD progression