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In season one, a minor background character dubbed Vape Girl rocketed to popularity, known for delivering sage advice and zippy one-liners, usually while prominently vaping

[132] [142] [143] Once nucleus accumbens FosB is sufficiently overexpressed, it begins to increase the severity of addictive behavior (i.e., compulsive drug-seeking) with further increases in its expression

[40] It was followed by France in February 2025 [41] and the United Kingdom in June 2025

The study also highlights the possibility of a healthy switcher effect, whereby smokers who successfully transition away from combustible cigarettes may differ systematically from those who continue smoking