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Recently, Carmi et al (106) found that myeloid cells released IL-1 and induced endothelial cells to produce proangiogenic factors, such as VEGF, and subsequently provided the inflammatory microenvironment for tumor progression and angiogenesis

Altogether, the European and African hotspots indicate moderate but consistent contamination patterns, suggesting that even regions with comparatively strong waste management systems may still exhibit localized failures requiring targeted interventions