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In a study of 124 patients admitted for acute myocardial infarction [87] who reported marijuana use and controlled for other triggers, there was a 4.8-fold increase in the risk of myocardial infarction (95% confidence interval [CI] 2.49.5, p = 0.001) in the first hour following marijuana use as compared with periods of non-use
To justify a flavored product, the applicant has to meet a comparative efficacy test. This test requires clinical trials or cohort studies to show that more adults stop smoking with a single flavored product than with a tobacco-flavored product
In addition, patients with potentially premalignant or malignant pathology of the oral cavity often present risk factors similar to those involved in the black hairy tongue, such as tobacco and alcohol consumption
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