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The APOE4 genotype is the major genetic risk factor for Alzheimers disease, which is associated with epilepsy

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To avoid publication bias, where positive results linking smoking and disease are published, but negative studies that do not support this link remain unpublished, researchers have outlined methods of comprehensive searches of all available scientific literature, and statistical methods to ascertain the likely extent of negative studies sitting on the shelf, impacting final conclusions (IARC Working Group on the Evaluation of Carcinogenic Risk to Humans, 2004

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