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IARC monographs on the evaluation of carcinogenic risks to humans, Volume 77: Some industrial chemicals

If this regulation ultimately shifts millions of Americans from smokeless tobacco to cigarettes, the outcome would be increased exposure to the thousands of chemicals in cigarette smoke, many of which can contribute to cancer, heart disease and other adverse health effects

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This is further exacerbated in the presence of metabolic syndrome and increases the risk of diabetes, cardiovascular, and cerebrovascular events