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Furthermore, we found that while silencing 7nAChR by si CHRNA7 did not affect the Trp/Kyn ratio or Trp and Kyn concentrations, pretreatment of the cells with si CHRNA7 significantly antagonized the NNK- and CSE-induced reduction of the Trp/Kyn ratio (Fig

4 Discussion Since their emergence as an alternative to tobacco smoking cessation, electronic nicotine delivery systems (ENDS) have been gaining popularity globally, with increasing use among non-tobacco smoking groups such as youth and even children (7, 16, 55)

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