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The evolution from a widely popular product to a marginal one was a result of various factors, including shifting cultural norms, health concerns, and the rise of alternatives like nicotine patches, gums, and more recently, vaping
We did not estimate RRs separately for different locations, sexes (although the RR of prostate cancer was estimated only for males and of cervical and breast cancer only for females) or age groups (although this analysis was applied to disease endpoints in adults aged 30 years only and, as detailed below, age-specific estimates were produced for the five CVD outcomes)
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