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Mostly, its the unknown, the FDA says

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You will learn the peer-review based sugar-links with leaky gut, post-prandial (after meals) bacterial translocation, fatty liver disease, inflammation (and the new anti-inflammatory molecule on the block NLRP3-inflammasome and how sugar disables it), the specific sugar-cancer link especially with colon and breast cancers, an Uber-like transporter molecule, GLUT12, that is an unappreciated sugar and breast cancer connection, and even the protective off-label use of metformin in fighting these cancer/insulin resistance/sugar cross-talks

they-setter #5 2008 - fuse box under the ashtray, blue one on top row, 3 in from the right (changed mine last night)