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A substantial emerging literature demonstrates that the majority of adult vapers use flavored products when transitioning away from cigarettes and maintaining cigarette abstinence

Weak instruments (i.e., weak association with the risk factor and/or imprecise association with the outcome), horizontal pleiotropy (when genetic IVs affect the outcome through causal pathways unrelated to the exposure), heterogeneity in variant-specific effects, and errors in phenotype measurements (especially if these are biased) can limit applicability [20]

Feldmann R

The "spices" have an unpleasant smell, not like an exotic marketplace of your imagination but like you spent the day cooking curries and neglected to take a shower