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Funding: Qiang Fu was supported by National Cancer Institute grant (K07CA104119) and Li-Tzy Wu was supported by National Institutes of Health grants (DA027503, DA019623, and DA019901)

At least 16 countries have adopted a tobacco sales age of 21: Cook Islands, Ethiopia, Honduras, Indonesia, Ireland, Kazakhstan, Kuwait, Mongolia, Palau, Samoa, Singapore, Sri Lanka, Turkmenistan, Uganda, United States and Uzbekistan

Aside from toxicity, there are also risks from misuse or accidents such as contact with liquid nicotine [28] (Figure 5)

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