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Albeit the cEDS-specific triad, i.e., widened, atrophic scars (92% of patients and ~ 95% of probands), marked skin hyperextensibility (80% of patients and ~ 82% of probands), and gJHM (BS 5, ~ 59% of patients and ~ 66% of probands), is highly predictive for molecular confirmation of the diagnosis, this combination was observed only in ~ 49% of patients and in ~ 55% of probands

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Smoking during recovery raises the risk that the wound heals slowly or breaks down, that the lower skin edge dies (necrosis), and of infection, all of which can worsen the scar and may need further treatment

In the same way that a cochlear implant can restore hearing, in theory a device could be implanted, perhaps under the skin of the forehead, with a wire running to the olfactory bulb with an electrical stimulus. Sign me up