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And when the medications do collaterally inhibit other PDE enzymes, you may experience certain side effects, including: Facial reddening Headache Diarrhea Nausea or stomach discomfort More serious side effects could also occur, including: Priapism (an erection that lasts longer than four hours) Dizziness Vision changes Low blood pressure Side effects of sildenafil Sildenafils side effect profile is slightly more extensive compared with other as-needed PDE5 inhibitors, like vardenafil and avanafil (Stendra), mainly because those other drugs were developed later and have been designed to be more selective of the PDE5 enzyme