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The impact of smoking on subgingival microflora: from periodontal health to disease

The growth of common Streptococcus species, in particular Streptococcus intermedius , Streptococcus anguinis , and Streptococcus mutans from saliva are shown to be suppressed by prolonged exposure to the aqueous extracts of betel nut such as tannic acid ( Streptococcus anginosus , is shown to induce the synthesis of inflammatory cytokines and NO (Sasaki et al., 2001) signifying potential mechanisms of carcinogenesis

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