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Gundersen et al., documented a significant decrease in sperm concentration among cannabis users compared to non-users 52

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Metzler-Guillemain C, Victorero G, Lepoivre C et al (2015) Sperm mRNAs and microRNAs as candidate markers for the impact of toxicants on human spermatogenesis: an application to tobacco smoking

Pros: No nicotine, no tobacco, provides a mild energy boost, familiar pouch format Cons: Caffeine sensitivity may be an issue for some, doesn't replicate the nicotine "hit" Best for: People quitting nicotine who still want a stimulant effect, or anyone seeking an afternoon pick-me-up without coffee 4