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based on these correlation rates, it is estimated that the approximate number of mutations accumulated in a normal cell of each tissue due to smoking a pack of cigarettes per day for a year is 150, particularly in the lungs.12 A recent study showed that smoking duration alone reportedly provides stronger risk estimates of COPD than the composite index of pack-years.13 However, it remains unknown whether smoking duration can also replace pack-years for predicting smoking-related oncogenic mutations in non-small cell lung cancer (NSCLC)