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"The Global Smoking Epidemic: A History and Status Report"

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This provided estimates in each age category (45, 55, and 65 years) because the risk of cardiovascular disease changes with age.15 The reference value of 1.0 (never smokers) was not included in the regression to avoid forcing the model through the origin and unduly affecting the dose-response relation (also because we were ultimately interested only in comparing between high and low consumption)