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When smoking stops, CYP1A2 activity gradually returns to normal levels, which slows down drug metabolism and potentially leads to elevated concentrations that increase the likelihood of side effects such as sedation, dizziness, or gastrointestinal issues

Consequently, this may result in an escalation of the risk, occurrence, and/or severity of ADRs associated with bupropion exposure

The report also said the largest proportionate reduction in smoking would be among 15 to 17 year olds