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Additionally, McConkey et al., in 1967, observed the occurrence of transparent skin that was associated with a decrease in dermal collagen in postmenopausal women [21]

NAD+ is a coenzyme central to cellular energy metabolism, DNA repair, and mitochondrial function, with downstream antioxidant effects through sirtuins and PARP pathways

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Other therapeutic approaches targeting fibroblast ferroptosis have also emerged: the in vitro and in vivo experiments demonstrate that platelet-rich plasma (PRP) promotes healing of type 2 diabetic mouse ulcers by inhibiting fibroblast ferroptosis and improving functional impairment [78, 80], providing a new strategy for diabetic ulcer treatment