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AA is a basic precursor of numerous lipid-based signaling molecules and can be further transformed by cyclooxygenases (COX), lipoxygenases (LOX) and cytochrome p450 (CYP450) to form eicosanoids, further influencing redox balance and inflammation by engaging specific receptors 93

[1] Additionally, the authors indicate that there is still a requirement for successful human trials to be completed prior to clinical translation as there are important differences between rodent and human physiology that could have a significant impact on the efficacy and safety of any agent

2012 Nov-Dec;69(6):1303-6