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Comparison of cells from normal subjects and patients with homozygous familial hypercholesterolemia and abetalipoproteinemia

Key updates include: Annual screening for overweight and obesity Confirmation of excess adiposity beyond BMI when feasible Clear recognition that 57% weight loss improves glycemia and cardiometabolic risk Importantly, pharmacologic obesity treatment now emphasizes: Individualized dose titration Balancing efficacy with tolerability Considering alternative agents when response plateaus GLP-1 receptor agonists and dual GIP/GLP-1 therapies now sit at the center of metabolic care

The heterogeneity of MCAS, with its varied mutational profiles and aberrant expression of hundreds of potent mediators, creates chronic multisystem polymorbidity with inflammatory, allergic, and dystrophic phenotypes

NCT06047548