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Homologous recombination deficiency (HRD) caused by BRCA1/2 gene mutations leads to resistance to platinum-based chemotherapeutic agents, a phenomenon particularly evident in HGSOC ( The Homologous Recombination Deficiency (HRD) Score is a tool for predicting cancer patients' chemotherapy responses by assessing genomic instability ( Tumor Mutation Burden (TMB), defined as the number of mutations per million base pairs in tumor cells, has been recognized in recent years as an important biomarker for predicting responses to immunotherapy ( With the in-depth investigation of drug resistance mechanisms in HGSOC, the discovery of emerging biomarkers provides novel insights into managing resistance

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