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Cold therapy works through simple but powerful biological processes

This is mainly driven by a high prevalence of type 2 diabetes and obesity in the region

ferroptosis has been proposed to be involved in COVID-19-related brain injury (Zhang et al., 2022)

Statements Author contributions CJ wrote the section on direct and indirect evidence for the role of redox dysregulation in ALS, modifiers of redox regulation as a therapeutic target for ALS, contributed to all the figures and tables, and edited the manuscript throughout