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30 Additional Contributors Other conditions that can lead to CKD include 31-33 : Kidney damage caused by the long-term use of certain medications (see section titled What Medications Are Linked to Chronic Kidney Disease? below) Polycystic kidney disease, a genetic condition in which multiple large cysts form in the kidneys Autoimmune disorders such as lupus and Goodpastures disease, in which the kidneys undergo inflammatory damage Recurring or persistent kidney or systemic infections Long-term heavy metal exposure (eg, lead poisoning) Gout and high uric acid (bi-directional relationship) 4 Symptoms of Chronic Kidney Disease A major challenge with CKD is that it rarely causes symptoms before stages 4 and 5

The best explanation is that xenobiotics hit the gland directly via the arterial route, whereas ingested toxicants first encounter the liver which is best equipped to deal with RXS, via its huge complement of GSH and GST (21, 170)

These symptoms may occur because the medication can affect your nervous system slightly or cause dehydration if you dont drink enough fluids

Available online at: 42 Champix (2006)