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In the human estrogen receptor-positive MCF7 breast cancer cell line, GLP-1RA have consistently been reported to have anti-proliferative and pro-apoptotic effects ( in vitro , but exendin-4 reduced the proliferation ( In vivo , liraglutide was also reported to accelerate the growth of murine 4T1 cells in a syngeneic model ( Conclusion The possibility that a GLP-1RA may significantly improve lymphedema in patients with excess weight gain is an exciting one