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PTSD (ICD-10-CM code F43.1*) Medication for opioid use disorder (MOUD): ATC code N07BC* Medication for alcohol use disorder (MAUD): ATC code N07BB* Medication for nicotine dependence (MNUD): ATC code N07BA* Sensitivity analyses Alcohol initial overdose only Non-alcohol initial overdose only Patients with no MOUD , MAUD , or MNUD Model specifications Cox proportional hazards with GLP-1 exposure (active use, discontinued, never) as a time-varying covariate Limitations Confounding by indication: patients who initiate GLP-1s may be more engaged in healthcare, have different health-seeking behaviors, or differ systematically on unmeasured factors compared with patients who do not

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Available evidence comes from ingredient studies rather than the complete formulation