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Using the targeting of nanoparticles, the encapsulated engineered bacteria can specifically aggregate at the tumor site of HCC [145]
Some limitations of this study should be mentioned
Swallowing peptides that are protease-sensitive can render them inactive
Pooling RCT data with many zero events can lead to mathematical instability, and although the Mantel-Haeszel fixed-effect method has been shown to perform well for this situation [15], as a sensitivity analysis we also estimated the pooled RCT estimates using a fixed-effects Peto method and random-effects Poisson regression, which also allow for baseline study variability and any between-study heterogeneity [18, 19]
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