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The role of GLP-1R in AD is reflected mainly in the following aspects: it can decrease A deposition and inhibit tau protein hyperphosphorylation, reduce neuroinflammation and oxidative stress (OS) ( 2.1 GLP-1R and A deposition A is a protein fragment produced by the cleavage of amyloid precursor protein (APP) by a series of enzymes and is one of the key factors in AD research (Sambamurti et al., 2002