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Furthermore, different from the ordered -helical ECL1 in inactive GLP-1R 33 and -hairpin in inactive GCGR 36 that cover the binding pocket and probably block peptide insertion, ECL1 of active GLP-2R, GLP-1R and GCGR simultaneously move outward and stand upwards in line with TM2 and TM3

Vijay Shekar Reddy, Professor and Head of Endocrinology at Gandhi Hospital, Secunderabad, cautioned against viewing the drug as a simple or standalone solution

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