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Patients should not discontinue established lipid-lowering medications when initiating semaglutide unless specifically directed by their healthcare provider

(Wilding JPH et al., NEJM 2021) The SELECT trial (N=17,604), published in the New England Journal of Medicine in 2023, showed a 20% reduction in major adverse cardiovascular events (MACE) with semaglutide 2.4 mg in adults with existing cardiovascular disease and overweight or obesity but without diabetes (Lincoff AM et al., NEJM 2023)