For those of you who dont eat meat and dairy products , there are fortified foods on the market, like breakfast cereals, that can be used as a readily available source of vitamin B12

This classic sign typically appears in severe, prolonged iron deficiency Brittle nails : Increased fragility with splitting, peeling, or easy breakage at the free edge Pallor of the nail bed : The normally pink nail bed appears pale or white due to anaemia Vertical ridging : Longitudinal lines or grooves running from cuticle to tip, though these are also common with ageing and may not indicate deficiency Slow growth : Reduced nail growth rate compared to normal (approximately 3mm per month), though this is non-specific and occurs with ageing Nail changes occasionally associated with B12 deficiency include: Blue-grey or brown hyperpigmentation : Diffuse darkening of the nail plate, though this is rare Longitudinal melanonychia : Dark vertical bands, particularly in darker-skinned individuals Brittle texture : Similar to iron deficiency, with increased fragility Nail plate thinning : Overall reduction in nail thickness IMPORTANT : A new or changing dark band on a single nail requires urgent medical assessment, as this may indicate subungual melanoma (a form of skin cancer) rather than nutritional deficiency

All markers are interpreted against local reference ranges and the individual patient
5-Amino-1-methylquinolinium iodide is the lead first-in-class small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT) an enzyme overexpressed in white adipose tissue of obese individuals where it consumes the methyl-donor pool and depletes tissue NAD