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IGF-DES and the IGF-1R Signalling Network The IGF-1R is a cell-surface protein evolutionarily related to the insulin receptor, and its biological actions are moderated by IGFBPs that bind and transport the ligand in circulation

The mammalian target of rapamycin (mTOR), a key protein downstream of the phosphatidylinositol 3-kinase/protein kinase (PI3K/AKT) pathway, is closely associated with insulin metabolic dysfunction and exerts a substantial impact on the growth and proliferation of FGCs

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