semaglutide adolescent obesity trial 2022 GLP-1 prescribing among teens with Once-Weekly Semaglutide in Adolescents with

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10 Majority of patients had CVD and were receiving SOC 6,7,a 97% were receiving glucose-lowering medications 6 Patient characteristics at baseline (N=9650) 6,7 Select history of CVD at baseline (N=9650) 6 Select history of medication use at baseline (N=9650) 6,10 a Standard care consisted of glucose-lowering and cardiovascular riskreducing therapies administered in accordance with local guidelines

Key Takeaways BCBS coverage for Zepbound varies by state and plan type: There is no single BCBS policy each state affiliate and employer group sets its own formulary Prior authorization is almost always required: Even plans that cover Zepbound require clinical documentation before approving claims BMI thresholds typically apply: Most BCBS plans require a BMI 30, or 27 with a weight-related comorbidity like type 2 diabetes or hypertension Some BCBS affiliates have dropped GLP-1 coverage entirely: BCBS Michigan removed all GLP-1 weight loss drugs from fully insured commercial plans starting January 2025 Research-grade tirzepatide exists for laboratory use: Not a substitute for prescription medication, but available at significantly lower cost for research applications Zepbound (tirzepatide) launched in late 2023 as Eli Lilly's dedicated weight management version of Mounjaro

A recent study found that GLP-1 drugs like Ozempic and Wegovy may significantly reduce blood pressure