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In the SURMOUNT-1 trial, participants lost up to 22.5% of body weight over 72 weeks at the highest dose

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CAF-driven extracellular matrix remodeling including excessive deposition and crosslinking of collagen and fibronectin creates dense, stiff tumor architecture that physically limits intratumoral drug penetration, as demonstrated in pancreatic ductal adenocarcinoma and breast cancer This stromal barrier results in heterogeneous drug exposure, enabling protected tumor regions to survive otherwise effective systemic therapy (125, 126)

As it remains to be determined whether the interaction between increased butyrate-producing bacteria and improved glucose homeostasis is direct, we have observed elevated levels of Ffar2 and Ffar3 SCFA receptors in the colon of CB0313.1-treated mice (Fig